The Golestaneh Lab

photo showing the stages of aging in a mans face

General Information 

Dr. Golestaneh’s lab is investigating how aging mechanisms affect the cells and induce diseases such as age-related macular degeneration (AMD). Using patient-specific induced pluripotent stem (iPS) cells Dr. Golestaneh is studying the cellular and molecular mechanisms that induce the AMD and is developing ways to stop this disease from occurring. Another focus of the lab is developing new methods of autologous cell-based therapy for AMD by generating patient-specific stem cell-derived neuroretinal cells.

Contact Information

Nady Golestaneh, PhD 
Office Phone: (202) 687-4309 
Office Location: Med-Dent Building, Room NE 203 
Laboratory Location: Med-Dent Bldh Room NE 212-218

Publications

  • Yu CR, Oh HM, Golestaneh N, Amadi-Obi A, Lee YS, Eseonu A, Mahdi RM, Egwuagu CE.. “IL-2-expressing Th17 Cells Persist in Human Blood and Retina of Mice During Uveitis: Constitutive IL-2 expression Confers Survival Advantages to Th17..” Eur J Immunol. (2011).
  • Oh HM, Yu CR, Golestaneh N, Amadi-Obi A, Lee YS, Eseonu A, Mahdi RM, Egwuagu CE. “STAT3 Protein Promotes T-cell Survival and Inhibits Interleukin-2 Production through Up-regulation of Class O Forkhead Transcription Factors..” J Biol Chem. 286.35 (2011): 30888-97.
  • Kokkinaki M, Sahibzada N, Golestaneh N.. “Human induced pluripotent stem-derived retinal pigment epithelium (RPE) cells exhibit ion transport, membrane potential, polarized vascular endothelial growth factor secretion, and gene expression pat.” Stem Cells 29(5).May (2011): 825-35.
  • Kokkinaki M, Lee TL, He Z, Jiang J, Golestaneh N, Hofmann MC, Chan WY, Dym M.. “Age affects gene expression in mouse spermatogonial stem/progenitor cells..”Reproduction 139.6 (2010): 1011-20.
  • Kokkinaki M, Lee TL, He Z, Jiang J, Golestaneh N, Hofmann MC, Chan WY, Dym M.. “The molecular signature of spermatogonial stem/progenitor cells in the 6-day-old mouse testis..” Biol Reprod. 80.4 (2009): 707-17.
  • Golestaneh N, Kokkinaki M, Pant D, Jiang J, DeStefano D, Fernandez-Bueno C, Rone JD, Haddad BR, Gallicano GI, Dym M. “Pluripotent stem cells derived from adult human testes..” Stem Cells Dev. 18.8 (2009): 1115-26.
  • Golestaneh N, Beauchamp E, Fallen S, Kokkinaki M, Uren A, Dym M.. “Wnt signaling promotes proliferation and stemness regulation of spermatogonial stem/progenitor cells..” Reproduction 138.1 (2009): 151-62.
  • Golestaneh N, Fan J, Zelenka P, Chepelinsky AB.. “PKC putative phosphorylation site Ser235 is required for MIP/AQP0 translocation to the plasma membrane..” Mol Vis.29.14 (2008): 1006-14.
  • He Z, Jiang J, Kokkinaki M, Golestaneh N, Hofmann MC, Dym M.. “Gdnf upregulates c-Fos transcription via the Ras/Erk1/2 pathway to promote mouse spermatogonial stem cell proliferation..” Stem Cells 26.1 (2008): 266-78.
  • Kitisin K, Saha T, Blake T, Golestaneh N, Deng M, Kim C, Tang Y, Shetty K, Mishra B, Mishra L.. “Tgf-Beta signaling in development..” Sci STKE 399 (2007).
  • Golestaneh N, Tang Y, Katuri V, Jogunoori W, Mishra L, Mishra B.. “Cell cycle deregulation and loss of stem cell phenotype in the subventricular zone of TGF-beta adaptor elf-/- mouse brain..” Brain Res. 1108.1 (2006): 45-53.
  • Yang Y, Stopka T, Golestaneh N, Wang Y, Wu K, Li A, Chauhan BK, Gao CY, Cveklová K, Duncan MK, Pestell RG, Chepelinsky AB, Skoultchi AI, Cvekl A.. “Regulation of alphaA-crystallin via Pax6, c-Maf, CREB and a broad domain of lens-specific chromatin..” EMBO J. 25.10 (2006): 2107-18.
  • Golestaneh N, Mishra B.. “TGF-beta, neuronal stem cells and glioblastoma..” Oncogene 24.37 (2005): 5722-30.
  • Golestaneh N, Fan J, Fariss RN, Lo WK, Zelenka PS, Chepelinsky AB.. “Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires fibroblast growth factor-induced ERK and JNK signaling..” J Biol Chem. 279.30 (2004): 31813-22.
  • Golestaneh N, Picaud S, Mirshahi M.. “The mineralocorticoid receptor in rodent retina: ontogeny and molecular identity..” Mol Vis. 8 (2002): 221-5.
  • Mirshahi M, Ayani E, Nicolas C, Golestaneh N, Ferrari P, Valamanesh F, Agarwal MK.. “The blockade of mineralocorticoid hormone signaling provokes dramatic teratogenesis in cultured rat embryos..” Int J Toxicol 21.3 (2002): 191-9.
  • Golestaneh N, De Kozak Y, Klein C, Mirshahi M.. “Epithelial sodium channel and the mineralocorticoid receptor in cultured rat Müller glial cells..” Glia 33.2 (2001): 160-8.
  • Golestaneh N, Nicolas C, Picaud S, Ferrari P, Mirshahi M.. “The epithelial sodium channel (ENaC) in rodent retina, ontogeny and molecular identity..” Curr Eye Res. 21.3 (2000): 703-9.