Georgetown University Neurology Clinical Research (GUNCR)

Actively Enrolling Trials

(Current as of February 16th, 2022)

Click on the diagnoses below to see our actively enrolling trials

Click on the name of a trial to view the trial’s page on clinicaltrials.gov

ALS, Myasthenia Gravis (MG), & Spinal Muscular Atrophy (SMA)

Observational study to examine safety, tolerability, and effectiveness of SPINRAZA® prescribed as part of standard of care (SAS Trial)
- Study Coordinator: Sarai Bartlett (ssb92@georgetown.edu)
ALS Postmortem Tissue Bank
- Coordinator: Galam Khan, MD (gak2@georgetown.edu)

Epilepsy

Registry of Subjects With Drug Resistant Epilepsy and Treated With the VNS Therapy System. (CORE-VNS)
- Study Coordinator: Sandeep Pamula (sp1210@georgetown.edu)

Migraine and Headache Disorders

Efficacy, Safety, and Tolerability of Atogepant for the Prevention of Chronic Migraine (PROGRESS 3101-303-002)
- Study Coordinator: Chris Gough (ccg46@georgetown.edu)
A Study to Evaluate the Safety of STS101 in the Acute Treatment of Migraine (ASCEND)
- Study Coordinator: Chris Gough (ccg46@georgetown.edu)
Preventive Treatment of migraine: Outcomes for Patients in real-world Healthcare systems (TRIUMPH)
- Study Coordinator: Chris Gough (ccg46@georgetown.edu)

Multiple Sclerosis (MS)

A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (O’HAND)
- Study Coordinator: David Pisfil (ddp39@georgetown.edu)
Traditional Versus Early Aggressive Therapy for Multiple Sclerosis Trial (TREAT-MS)
- Study Coordinator: Derek Haase (drh57@georgetown.edu)
A Study To Evaluate The Efficacy And Safety Of Fenebrutinib Compared With Ocrelizumab In Adult Participants With Primary Progressive Multiple Sclerosis (GN41791 / FENtrepid)
- Study Coordinator: Sarai Bartlett (ssb92@georgetown.edu)
Study Describing Cognitive Processing Speed Changes in Relapsing Multiple Sclerosis Subjects Treated With Ozanimod (RPC-1063 / ENLIGHTEN)
- Study Coordinator: Sandeep Pamula (sp1210@georgetown.edu)
The MS-LINK™ Outcomes Study (MS-LINK)
- Study Coordinator: David Pisfil (ddp39@georgetown.edu)
Relapsing Forms of Multiple Sclerosis (RMS) Study of Bruton’s Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (GEMINI 1)
- Study Coordinator: David Pisfil (ddp39@georgetown.edu)
Study of Diroximel Fumarate in the Real-World Setting (EXPERIENCE)
- Study Coordinator: Sandeep Pamula (sp1210@georgetown.edu)

Neuromyelitis Optica (NMO)

A Study of the Safety and Activity of Eculizumab in Pediatric Participants With Relapsing Neuromyelitis Optica Spectrum Disorder (ECU-NMO-303)
- Study Coordinator: David Pisfil (ddp39@georgetown.edu)

Parkinson’s Disease (PD)

Clinical Effect of Ampreloxetine (TD-9855) for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure (Theravance / SEQUOIA)
- Study Coordinator: Sandeep Pamula (sp1210@georgetown.edu)

Orally Administered ENT-01 for Parkinson’s Disease-Related Constipation (KARMET)
- Study Coordinator: Luke Lovelace (LL928@georgetown.edu)
Product Surveillance Registry (PSR)
- Study Coordinator: David Pisfil (ddp39@georgetown.edu)
PROSEEK: A Phase 2 Study In Early Parkinson’s Disease Patients Evaluating The Safety And Efficacy Of Abl Tyrosine Kinase Inhibition Using K0706 (CLR_18_06 / PROSEEK)
- Study Coordinator: Luke Lovelace (LL928@georgetown.edu)
Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension (RESTORE)
- Study Coordinator: Sandeep Pamula (sp1210@georgetown.edu)
A Clinical Study of NLY01 in Patient’s With Early Parkinson’s Disease (Neuraly / NLY01-PD-1)
- Study Coordinators: Luke Lovelace (LL928@georgetown.edu) and Sandeep Pamula (sp1210@georgetown.edu)

Stroke

AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke (ARCADIA)
- Study Coordinator: Derek Haase (drh57@georgetown.edu)

A Safety and Efficacy Study of Intravenous (IV) Elezanumab Assessing Change in Neurologic Function in Adult Participants With Acute Ischemic Stroke (M19-148 / EAISE)
- Study Coordinator: Derek Haase (drh57@georgetown.edu)

Current Staff